Fig. 1

Different EAE outcomes in SCH-immunized DA rats. DA rats were immunized with SCH and scored daily for clinical signs. A Representative plots of clinical outcomes are presented. B Grouped clinical outcomes. C Distribution of rats among groups (n = 106). D–H Parameters of EAE. I Correlation matrix of EAE parameters (n = 106). Data are presented as mean ± SEM (B) or mean ± SD (D–H) from 10 (mild), 31 (moderate), 35 (severe), and 30 (lethal) obtained in 6 independent experiments. *p < 0.05, ****p < 0.001, ns—not significant