Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Remibrutinib (LOU064) inhibits neuroinflammation driven by B cells and myeloid cells in preclinical models of multiple sclerosis

Fig. 7

Remibrutinib inhibits IC-induced TNFα secretion from human iMicroglia in vitro. Four different iMicroglia batches were tested independently and showed varying levels of IC-induced TNFα (batches are color coded). Batch response was normalized to maximal TNFα secretion and concentration response curves to remibrutinib were calculated using a four-parameter logistic regression. Remibrutinib inhibited TNFα secretion with an IC50 of 1.1 nM

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094