Fig. 7
From: Chemogenetic activation of locus coeruleus neurons ameliorates the severity of multiple sclerosis
The effect of late chronic LC activation on cortical astrocyte activation and noradrenergic projections. Representative images showing astrocyte activation in the A PL/IL and C M2/M1 cortices, and B, D the quantification of GFAP immunoreactivity (IR) in arbitrary units (AU). Representative images showing DBH positive fibers in E the dorsal and F ventral horns (DH, VH) of the lumbar spinal cord, H PL/IL and J M2/M1 cortices, and G, I, K the quantification of DBH IR in AU. The data represent the mean + SEM and each point corresponds to an individual mouse (n = 4–5 per group). #p < 0.05; ###p < 0.001 EAE versus naïve; *p < 0.05, **p < 0.01 EAE-rM3Dpeak versus EAE (Additional file 1: Table S8). Scale bars: A, C, 200 µm; E, F, H, J, 100 µm