Fig. 2
From: Topographic distribution of inflammation factors in a healing aneurysm
Evolution of aneurysm healing without and with coil treatment. Longitudinal cuts of the aneurysm complex following natural course (top row) and coil (*) treatment (bottom row), 3 days (A, C), 7 days (B, D) and 21 days (E) into the healing process. Note the absence of cells in the aneurysm wall. After 3 days of coil treatment (C) there is already a small tissue layer, separating the lumen of the adjacent vessel (AV) from the early hematoma (H) in the aneurysm sac, which develops into a thick neointima (N). Early hematoma is gradually transformed (D) into mature thrombus (T) with only minimal residual hematoma in the top part of the aneurysm sac after 3 weeks (E). In the absence of coils, the intra-aneurysmal hematoma shows massive neutrophile invasion, insufficient thrombus maturation and remaining central residual aneurysm perfusion (B)