Fig. 3

Effects of LP and LB on release of inflammatory factors (n = 6). A The levels of IL-1, IL-6, TNF-α in peripheral blood at the beginning of the disease (day 11 of immunization), and the LP treatment group was able to downregulate TNF-α and IL-6 compared with the model group, but there was no statistical significance (p > 0.1). B IL-1, IL-6, TNF-α levels measured by peripheral blood during the peak incidence period (day 19 of immunization). At peak, the levels of inflammatory factors were upregulated in the EAN model group, while levels of all inflammatory factors were downregulated in the LP treatment group, and expression of TNF-α was downregulated by LB. (*p < 0.1, **p < 0.01, ***p < 0.001, ****p < 0.0001)