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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Injection of amyloid-β to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer’s disease

Fig. 6

Aβ1–42 i.c.v reduced the M1 type acetylcholine receptors (M1 mAChR) expression in hippocampus and cortex. A, D Immunofluorescence and quantification of M1 mAChR in in hippocampus (CA1, CA3 and DG), and cortex of each group. Scale bars, 200 μm. C, E Immunofluorescence and quantification of TMEM119 in hippocampus DG of each group. Scale bars, 200 μm. B, F, G, H Western blot and quantification of synapsin 1, PSD95, and M1 mAChR in colon of each group. n = 6 per group. Data were presented as mean ± SEM. Statistics were analyzed using one-way analysis of variance (ANOVA) and followed by Fisher’s least significant difference (LSD) test. ∗ P < 0.05, **P < 0.01, ns no statistical difference

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Journal of Neuroinflammation

ISSN: 1742-2094