Fig. 3

Line graph displaying the percentage of studies that observed significant upregulation in IL-1β, TNFα, IL-6, and IL-10. The majority of investigators observe a significant upregulation of the three most investigated inflammatory cytokines early after injury and TNFα and IL-1β remain upregulated. The anti-inflammatory cytokine IL-10 lags further behind and the majority of investigators show it peaking around 1-week post-injury